Dehydrated Alcohol Injection and Doxycycline Delayed-Release Tablets
Determining the interaction of Dehydrated Alcohol Injection and Doxycycline Delayed-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Chronic alcohol consumption may enhance the elimination of doxycycline. The mechanism is induction of hepatic microsomal enzymes by alcohol. In one study, the half-life of doxycycline in six alcoholics was 10.5 hours, compared with 14.7 hours in six control patients. In addition, half the alcoholic patients had serum concentrations below what is generally considered the minimum therapeutic concentration (0.5 mcg/mL) at 12 to 24 hours after the dose. The investigators suggest that twice-a-day dosing may be indicated in these patients, especially if additional inducing drugs are used. The elimination of other tetracyclines probably is not affected by alcohol consumption.
- Neuvonen PJ, Penttila O, Roos M, Tirkkonen J "Effect of long-term alcohol consumption on the half-life of tetracycline and doxycycline in man." Int J Clin Pharmacol Biopharm 14 (1976): 303-7
Generic Name: ethanol
Brand name: Ablysinol
Synonyms: Alcohol
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dehydrated Alcohol Injection-Doxycycline Hyclate
- Dehydrated Alcohol Injection-Doxycycline Hyclate Delayed Release
- Dehydrated Alcohol Injection-Doxycycline Hyclate eent
- Dehydrated Alcohol Injection-Doxycycline Hyclate Tablets
- Dehydrated Alcohol Injection-Doxycycline Injection
- Dehydrated Alcohol Injection-Doxycycline Monohydrate
- Doxycycline Delayed-Release Tablets-Dekpak 13 Day Taperpak
- Doxycycline Delayed-Release Tablets-Del-Beta
- Doxycycline Delayed-Release Tablets-Delacort
- Doxycycline Delayed-Release Tablets-Delafloxacin
- Doxycycline Delayed-Release Tablets-Delafloxacin Injection
- Doxycycline Delayed-Release Tablets-Delafloxacin Intravenous