Dekpak 13 Day Taperpak and Diacomit
Determining the interaction of Dekpak 13 Day Taperpak and Diacomit and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of stiripentol, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 1A2, 2C19, and/or 3A4 may decrease the plasma concentrations of stiripentol, which has been shown in vitro to undergo phase I metabolism via these pathways. Pharmacokinetic studies have not been conducted. In a retrospective analysis of 220 stiripentol serum concentrations derived from 75 patients in three German epilepsy centres, concomitant use of phenobarbital or phenytoin (n=7) was associated with a 63% decrease in stiripentol serum concentrations.
MANAGEMENT: The potential for diminished pharmacologic effects of stiripentol should be considered during coadministration with CYP450 inducers. Alternative treatments may be required if an interaction is suspected.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Diacomit (stiripentol)." Biocodex Inc, Creswell, OR.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: dexamethasone
Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: DexPak 10 Day Taperpak, DexPak 10 Day TaperPak
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dekpak 13 Day Taperpak-Dialyvite
- Dekpak 13 Day Taperpak-Dialyvite 3000
- Dekpak 13 Day Taperpak-Dialyvite 5000
- Dekpak 13 Day Taperpak-Dialyvite 800/Iron
- Dekpak 13 Day Taperpak-Dialyvite Supreme D
- Dekpak 13 Day Taperpak-Dialyvite Vitamin D 5000
- Diacomit-Del-Beta
- Diacomit-Delacort
- Diacomit-Delafloxacin
- Diacomit-Delafloxacin Injection
- Diacomit-Delafloxacin Intravenous
- Diacomit-Delafloxacin Meglumine