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Delavirdine and Xanax

Determining the interaction of Delavirdine and Xanax and the possibility of their joint administration.

Check result:
Delavirdine <> Xanax
Relevance: 19.04.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ALPRAZolam and delavirdine is not recommended. Taking these drugs together can cause symptoms of prolonged drowsiness, dizziness, confusion, or weak or shallow breathing. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The coadministration with delavirdine may significantly increase the plasma concentrations and pharmacologic effects of alprazolam, midazolam, and triazolam. The mechanism is delavirdine inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme that metabolizes these benzodiazepines.

MANAGEMENT: Given the potential for serious and/or life-threatening reactions such as prolonged or increased sedation and respiratory depression, concomitant use of midazolam or triazolam with delavirdine is considered contraindicated.

References
  • "Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn, Kalamazoo, MI.
Delavirdine

Generic Name: delavirdine

Brand name: Rescriptor

Synonyms: n.a.

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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