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Delavirdine Mesylate and Emtricitabine, rilpivirine, and tenofovir

Determining the interaction of Delavirdine Mesylate and Emtricitabine, rilpivirine, and tenofovir and the possibility of their joint administration.

Check result:

Delavirdine Mesylate <> Emtricitabine, rilpivirine, and tenofovir

Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using rilpivirine together with delavirdine. Combining these medications may decrease the blood levels of rilpivirine, which may reduce its effectiveness in treating HIV infection. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant use of other nonnucleoside reverse transcriptase inhibitors (NNRTIs), such as efavirenz, etravirine, and nevirapine, may reduce the plasma concentrations of rilpivirine, which may increase the risk of treatment failure and emergence of drug resistance associated with subtherapeutic levels of rilpivirine. The concomitant use of delavirdine may increase plasma concentrations of rilpivirine.

MANAGEMENT: The manufacturer recommends against coadministration of rilpivirine with other NNRTIs.

References

"Product Information. Edurant (rilpivirine)." Tibotec Pharmaceuticals, Titusville, NJ.

Delavirdine Mesylate

Generic Name: delavirdine

Brand name: Rescriptor

Synonyms: Delavirdine

What is Delavirdine Mesylate?

Emtricitabine, rilpivirine, and tenofovir

Generic Name: emtricitabine / rilpivirine / tenofovir

Brand name: Complera, Odefsey

Synonyms: Emtricitabine, Rilpivirine, and Tenofovir Disoproxil Fumarate

What is Emtricitabine, rilpivirine, and tenofovir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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