Delavirdine Mesylate and Fluphenazine hydrochloride

• Generic Name: delavirdine
• Dosage Forms: n.a.
• Other Brand Names: Rescriptor

Treatment of HIV-1 infection in adults; usually used in conjunction with 2 HIV nucleoside reverse transcriptase inhibitors (NRTIs).

Experts state delavirdine not recommended for initial treatment regimens in antiretroviral-naive adults because of inferior virologic efficacy and inconvenient dosing regimen.

Data insufficient comparing delavirdine regimens to the preferred 3-drug regimens for initial treatment in antiretroviral-naive adults; consider that the proportion of clinical study patients responding to regimen of delavirdine and 2 NRTIs with sustained plasma HIV-1 levels <400 copies/mL over 1 year has been relatively low.

• Generic Name: fluphenazine
• Dosage Forms: n.a.
• Other Brand Names: Permitil, Prolixin, Prolixin Decanoate, Prolixin Enanthate

Symptomatic management of psychotic disorders (i.e., schizophrenia).

The long-acting decanoate ester is used mainly for maintenance therapy in patients with chronic schizophrenic disorder who cannot be relied on to take oral antipsychotic drugs; do not use for acute management of severely agitated patients.

Efficacy not established for management of behavioral complications in mental retardation.