Delstrigo and Sustiva (Efavirenz Capsules)
Determining the interaction of Delstrigo and Sustiva (Efavirenz Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Efavirenz may significantly reduce the blood levels of doravirine, which may make the medication less effective in treating HIV infection. Additionally, it may lead to development of viral resistance to this and various other HIV medications that are currently used for treatment. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may significantly decrease the plasma concentrations of doravirine, which is primarily metabolized by the isoenzyme. Some non-nucleoside reverse transcriptase inhibitors such as efavirenz, etravirine, and nevirapine are known inducers of CYP450 3A4. When doravirine 100 mg once daily was initiated following cessation of treatment with efavirenz 600 mg once daily in 17 study subjects, doravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (C24hr) decreased by an average of 35%, 62% and 85%, respectively, on the first day and 14%, 32% and 50%, respectively, 14 days later. Reduced efficacy of doravirine may occur.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of doravirine with efavirenz, etravirine, or nevirapine should generally be avoided.
- "Product Information. Pifeltro (doravirine)." Merck & Company Inc, Whitehouse Station, NJ.
Generic Name: doravirine / lamivudine / tenofovir
Brand name: Delstrigo
Synonyms: n.a.
Generic Name: efavirenz
Brand name: Sustiva
Synonyms: Sustiva
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Delstrigo-Sustiva (Efavirenz Tablets)
- Delstrigo-Sustol
- Delstrigo-Sustol injection
- Delstrigo-SuTan
- Delstrigo-SuTan-DM
- Delstrigo-Sutent
- Sustiva (Efavirenz Capsules)-Delsym
- Sustiva (Efavirenz Capsules)-Delsym Adult Night Time Multi-Symptom
- Sustiva (Efavirenz Capsules)-Delsym Cough Plus Chest Congestion DM
- Sustiva (Efavirenz Capsules)-Delsym Cough Plus Cold Day Time
- Sustiva (Efavirenz Capsules)-Delsym Cough Plus Cold Night Time
- Sustiva (Efavirenz Capsules)-Delsym Cough Relief