Deltuss DMX and Eldepryl Oral
Determining the interaction of Deltuss DMX and Eldepryl Oral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using selegiline together with dextromethorphan is not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. In general, you should wait at least 14 days after stopping selegiline before you start treatment with dextromethorphan. Conversely, if you have recently been on dextromethorphan and are now starting treatment with selegiline, you should check with your doctor or pharmacist to see how long you should wait before it is safe for you to use selegiline, as some medications can take a while to clear from your body. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: By inhibiting serotonin metabolism, monoamine oxidase inhibitors (MAOIs) may potentiate the pharmacologic activity of serotonergic agents such as serotonin reuptake inhibitors, 5-HT1 receptor agonists, ergot alkaloids, buspirone, dextromethorphan, and most antidepressants. The result may be an increased risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
MANAGEMENT: In general, serotonergic agents should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with serotonergic agents. A washout period of 5 to 14 days is usually recommended when switching from another antidepressant to an MAOI; however, the individual product labeling should be consulted.
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Generic Name: dexchlorpheniramine / dextromethorphan / pseudoephedrine
Brand name: Deltuss DMX, Abatuss DMX, Bromatan Plus, SuTan-DM, Tanafed DMX, Tannate DMP-DEX, C-Phed DPD Tann, Tanafed-DMX, DuraTan Forte, Dur-Tann Forte, TanDur DM, Tannate PD-DM
Synonyms: n.a.
Generic Name: selegiline
Brand name: Eldepryl, Zelapar, Emsam
Synonyms: Eldepryl, Eldepryl Capsules
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Deltuss DMX-Eldepryl Tablets
- Deltuss DMX-ELenzaPatch
- Deltuss DMX-Elepsia XR
- Deltuss DMX-Elestrin
- Deltuss DMX-Elestrin Transdermal
- Deltuss DMX-Eletriptan
- Eldepryl Oral-Deltuss DP
- Eldepryl Oral-Delyla
- Eldepryl Oral-Delzicol
- Eldepryl Oral-Demadex
- Eldepryl Oral-Demadex Intravenous
- Eldepryl Oral-Demeclocycline