Demeclocycline and Sodium Citrate and Citric Acid Oral Solution
Determining the interaction of Demeclocycline and Sodium Citrate and Citric Acid Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sodium citrate together with demeclocycline may decrease the effects of demeclocycline. Administration of sodium citrate and demeclocycline should be separated by three to four hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve increased renal elimination of tetracyclines when the urine becomes alkalinized. Information is available for doxycycline, tetracycline, and sodium bicarbonate only.
MANAGEMENT: If these drugs must be used together, an alternating dosing schedule is recommended (three to four hours apart).
- Elliott GR "Sodium bicarbonate and oral tetracycline." Clin Pharmacol Ther 13 (1972): 459
- Jaffe JM, Colaizzi JI, Poust RI, McDonald RH Jr "Effect of altered urinary pH on tetracycline and doxycycline excretion in humans." J Pharmacokinet Biopharm 1 (1973): 267-82
- Jaffe JM, Poust RI, Feld SL, Colaizzi JL "Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans." J Pharm Sci 63 (1974): 1256-60
Generic Name: demeclocycline
Brand name: Declomycin
Synonyms: n.a.
Generic Name: citric acid / sodium citrate
Brand name: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit, Shohl's Solution, Virtrate-2
Synonyms: Citric acid and sodium citrate, Sodium Citrate and Citric Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Demeclocycline-Sodium Citrate Anticoagulant Solution
- Demeclocycline-Sodium Diuril
- Demeclocycline-Sodium Edecrin
- Demeclocycline-Sodium Ferric Gluconate
- Demeclocycline-Sodium ferric gluconate complex
- Demeclocycline-Sodium ferric gluconate complex Intravenous
- Sodium Citrate and Citric Acid Oral Solution-Demeclocycline Hydrochloride
- Sodium Citrate and Citric Acid Oral Solution-Demerol
- Sodium Citrate and Citric Acid Oral Solution-Demerol (Meperidine Injection)
- Sodium Citrate and Citric Acid Oral Solution-Demerol (Meperidine Syrup and Oral Solution)
- Sodium Citrate and Citric Acid Oral Solution-Demerol (Meperidine Tablets)
- Sodium Citrate and Citric Acid Oral Solution-Demerol Injection