Demerol Injection and Marcaine/Epinephrine
Determining the interaction of Demerol Injection and Marcaine/Epinephrine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One in vitro study has suggested that meperidine may displace bupivacaine from plasma protein-binding sites. Theoretically, the risk of toxicity from the local anesthetic could be increased.
- Ghoneim MM, Pandya H "Plasma protein binding of bupivacaine and its interaction with other drugs in man." Br J Anaesth 46 (1974): 435-8
Generic Name: meperidine
Brand name: Demerol, Demerol HCl, Meperitab
Synonyms: Demerol
Generic Name: bupivacaine / epinephrine
Brand name: Marcaine/Epinephrine, Marcaine/Epinephrine PF, Sensorcaine-MPF/EPINEPHrine, Sensorcaine/EPINEPHrine
Synonyms: Marcaine with Epinephrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Demerol Injection-Marcaine/Epinephrine PF
- Demerol Injection-Mardrops-EX
- Demerol Injection-Margesic
- Demerol Injection-Margesic Oral
- Demerol Injection-Marinol
- Demerol Injection-Marlissa
- Marcaine/Epinephrine-Demser
- Marcaine/Epinephrine-Demulen 1/35
- Marcaine/Epinephrine-Demulen 1/50
- Marcaine/Epinephrine-Denavir
- Marcaine/Epinephrine-Denavir Topical
- Marcaine/Epinephrine-Dendracin Neurodendraxcin