Demerol Injection and Repan

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using meperidine together with other medications that cause central nervous system depression such as butalbital can lead to serious side effects including respiratory distress, coma, and even death. Additionally, medications like butalbital can sometimes increase the blood levels of a metabolic byproduct of meperidine that has been associated with seizures. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, you should avoid driving or operating hazardous machinery until you know how these medications affect you. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Barbiturates may potentiate the central nervous system (CNS) depressant effects of opioids such as meperidine. Concomitant use may result in profound sedation, respiratory depression, coma, and death. Barbiturates can also induce the hepatic metabolism of meperidine and increase the formation of normeperidine, a toxic metabolite that is thought to have CNS stimulant effects and has been associated with adverse effects such as irritability, anxiety, tremor, myoclonus, and seizures.

MANAGEMENT: The use of opioids in conjunction with other CNS depressants such as barbiturates should generally be avoided unless alternative treatment options are inadequate. If coadministration is necessary, the dosage and duration of each drug should be limited to the minimum required to achieve desired clinical effect, and patients should be closely monitored for signs and symptoms of CNS and respiratory depression. Patients receiving meperidine with barbiturates should also be cautioned about the potential for seizures. A dosage adjustment for one or both drugs may be required.

Demerol Injection

Generic Name: meperidine

Brand name: Demerol, Demerol HCl, Meperitab

Synonyms: Demerol

What is Demerol Injection?

Repan

Generic Name: acetaminophen / butalbital / caffeine

Brand name: Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S, Alagesic LQ

Synonyms: n.a.

What is Repan?