Demulen 1/50 and Tipranavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with tipranavir may increase your risk of developing a skin rash. If a rash occurs, it is usually mild to moderate. Nevertheless, you should be instructed to contact their doctor promptly. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Use of tipranavir in combination with estrogens may be associated with an increased risk of skin rash. The mechanism has not been described. Mild to moderate rashes including urticarial rash, maculopapular rash, and possible photosensitivity have been reported in 14% of females and 8% to 10% of males receiving tipranavir in combination with low-dose ritonavir in phase 2 and 3 trials. However, in one drug interaction trial, 33% of healthy female volunteers administered a single dose of ethinyl estradiol followed by tipranavir/ritonavir developed a rash. Rash accompanied by joint pain or stiffness, throat tightness, or generalized pruritus has also been reported in both men and women.

MANAGEMENT: Women who use estrogens should be advised of a potentially increased risk of skin rash during concomitant treatment with tipranavir. If a rash occurs, it is usually mild to moderate. Nevertheless, patients should be instructed to contact their physician promptly, as a temporary discontinuation of tipranavir or the estrogen may be necessary.

Demulen 1/50

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Demulen 1/50 (Oral)

What is Demulen 1/50?

Tipranavir

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Tipranavir?