Denileukin Diftitox and Ivacaftor

• Generic Name: denileukin diftitox
• Dosage Forms: n.a.
• Other Brand Names: Ontak

Treatment of persistent or recurrent cutaneous T-cell lymphoma (CTCL) in patients whose malignant cells express the CD25 component of the IL-2 receptor (designated an orphan drug by FDA for this use).

Safety and efficacy in patients with CTCL whose malignant cells do not express the CD25 component of the IL-2 receptor not established but currently being studied.

• Generic Name: ivacaftor
• Dosage Forms: n.a.
• Other Brand Names: Kalydeco

Ivacaftor is used to treat cystic fibrosis in adults and children who are at least 6 months old and weigh at least 11 pounds (5 kilograms).

Ivacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take ivacaftor, you may need a medical test to make sure you have this gene mutation.

Ivacaftor may also be used for purposes not listed in this medication guide.