Denileukin Diftitox and Xermelo

• Generic Name: denileukin diftitox
• Dosage Forms: n.a.
• Other Brand Names: Ontak

Treatment of persistent or recurrent cutaneous T-cell lymphoma (CTCL) in patients whose malignant cells express the CD25 component of the IL-2 receptor (designated an orphan drug by FDA for this use).

Safety and efficacy in patients with CTCL whose malignant cells do not express the CD25 component of the IL-2 receptor not established but currently being studied.

• Generic Name: telotristat
• Dosage Forms: tablet
• Other Brand Names: Xermelo

Xermelo works by blocking the production of serotonin in the body. In people who have carcinoid syndrome, serotonin is over-produced and causes symptoms of diarrhea or frequent bowel movements, stomach pain, and flushing (warmth, redness, or tingly feeling).

Xermelo is used to treat carcinoid syndrome diarrhea.

Xermelo may also be used for purposes not listed in this medication guide.