Depacon and Rifampin
Determining the interaction of Depacon and Rifampin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with valproic acid may decrease the effects of valproic acid. Contact your doctor if your condition changes or if you experience a loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Rifampin may significantly increase the oral clearance of valproate resulting in reduced plasma concentrations. Clearance of single valproate doses increased by 40% in healthy subjects when given after 5 days of rifampin administration. The exact mechanism of interaction has not been established, but induction of valproate metabolism by rifampin is suspected.
MANAGEMENT: Monitoring for altered efficacy is recommended. Patients should be advised to notify their physician if they experience a loss of seizure control or other signs of reduced efficacy. Dosage adjustments may be required if an interaction is suspected.
- "Product Information. Depacon (valproic acid)." Abbott Pharmaceutical, Abbott Park, IL.
- Bachmann KA, Jauregui L "Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo." Xenobiotica 23 (1993): 307-15
Generic Name: valproic acid
Brand name: Depacon, Depakene, Stavzor, Valproate Sodium
Synonyms: n.a.
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depacon-Rifampin and Isoniazid
- Depacon-Rifampin Capsules
- Depacon-Rifampin Injection
- Depacon-Rifampin Intravenous
- Depacon-Rifampin Oral, Intravenous
- Depacon-Rifampin, Isoniazid, and Pyrazinamide
- Rifampin-Depade
- Rifampin-Depakene
- Rifampin-Depakene (Valproic Acid Capsules)
- Rifampin-Depakene (Valproic Acid Liquid)
- Rifampin-Depakote
- Rifampin-Depakote (Divalproex Long-Acting Tablets)