Depade and Ocaliva

• Generic Name: naltrexone
• Dosage Forms: n.a.
• Other Brand Names: Depade, ReVia, Vivitrol

• It is used to help keep you alcohol-free.
• It is used to keep a drug-free state.
• It may be given to you for other reasons. Talk with the doctor.

• Generic Name: obeticholic acid
• Dosage Forms: tablet, film coated
• Other Brand Names: Ocaliva

Ocaliva (obeticholic acid) is a prescription medicine used to treat primary biliary cholangitis (PBC). This medicine is sometimes used together with another drug called ursodeoxycholic acid (UDCA).

Primary biliary cholangitis (PBC) is a chronic liver disease that gradually destroys bile ducts in the liver. These ducts deliver bile to the small intestines, to help your body digest fats and nutrients. When PBC destroys these ducts, the bile stays in your liver and damages its cells. This can lead to cirrhosis (scarring of the liver) and liver failure. PBC is a progressive disease that may have no symptoms for many years. Treating PBC can help keep the liver functioning normally.

Ocaliva was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people with PBC responded to this medicine, but further studies are needed.

It is not known if taking Ocaliva will improve your chance of survival or improve your symptoms of PBC.