Depakene and Neoprofen Intravenous
Determining the interaction of Depakene and Neoprofen Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: n.a.
Generic Name: ibuprofen
Brand name: Caldolor, NeoProfen, Advil, Advil Liqui-Gels, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength
Synonyms: NeoProfen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depakene-Neoral
- Depakene-Neoral (Cyclosporine Capsules, Modified)
- Depakene-Neoral (Cyclosporine Oral Solution, Modified)
- Depakene-Neoral Oral
- Depakene-Neosar
- Depakene-Neosporin + Pain Relief Ointment
- Neoprofen Intravenous-Depakene (Valproic Acid Capsules)
- Neoprofen Intravenous-Depakene (Valproic Acid Liquid)
- Neoprofen Intravenous-Depakote
- Neoprofen Intravenous-Depakote (Divalproex Long-Acting Tablets)
- Neoprofen Intravenous-Depakote (Divalproex Sprinkle Capsules)
- Neoprofen Intravenous-Depakote Capsules