Depakene (Valproic Acid Liquid) and Ibuprofen and Famotidine
Determining the interaction of Depakene (Valproic Acid Liquid) and Ibuprofen and Famotidine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Depakene
Generic Name: famotidine / ibuprofen
Brand name: Duexis
Synonyms: Famotidine and ibuprofen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Ibuprofen and Famotidine-Depakote DR
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