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Depakote and Equetro

Determining the interaction of Depakote and Equetro and the possibility of their joint administration.

Check result:

Depakote <> Equetro

Relevance: 21.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking carBAMazepine, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter the effects of both medications. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Carbamazepine usually decreases valproate levels, and valproate may alter carbamazepine levels in unpredictable ways. Additionally, valproate may prolong the elimination half-life of carbamazepine epoxide. Multiple complex mechanisms may be involved.

MANAGEMENT: Patients who must take both drugs should be carefully monitored for clinical and laboratory evidence of altered effects, particularly when the dosage of either drug is changed.

References

Kondo T, Otani K, Hirano T, et al "The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid." Br J Clin Pharmacol 29 (1990): 116-9
Sackellares JC, Sato S, Dreifuss FE, Penry JK "Reduction of steady-state valproate levels by other antiepileptic drugs." Epilepsia 22 (1981): 437-41
Pisani F, Caputo M, Fazio A, et al "Interaction of carbamazepine, with valproate: a pharmacokinetic study." Epilepsia 31 (1990): 339-42
Tohen M, Castillo J, Pope HG, Herbstein J "Concomitant use of valproate and carbamazepine in bipolar and schizoaffective disorders." J Clin Psychopharmacol 14 (1994): 67-70
Koup JR, Toothaker RD, Posvar E, et al "Theophylline dosage adjustment during enoxacin coadministration." Antimicrob Agents Chemother 34 (1990): 803-7
Jann MW, Fidone GS, Israel MK, Bonadero P "Increased valproate serum concentrations upon carbamazepine cessation." Epilepsia 29 (1988): 578-81
Ahuja YR, Jaju M, Jaju M "Chromosone-damaging action of isoniazid and thiacetazone on human lymphocyte cultures in vivo." Hum Genet 57 (1981): 321-2
Adams DJ, Luders H, Pippenger C "Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study." Neurology 28 (1978): 152-7
Levy RH, Moreland TA, Morselli PH, et al "Carbamazepine/valproic acid interaction in man and rhesus monkey." Epilepsia 25 (1984): 338-45
Henriksen O, Johannessen SI "Clinical and pharmacokinetic observations on sodium valproate: a 5-year follow-up study in 100 children with epilepsy." Acta Neurol Scand 65 (1982): 504-23
Riva R, Albani F, Contin M, Baruzzi A "Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations." Clin Pharmacokinet 31 (1996): 470-93

Depakote

Generic Name: divalproex sodium

Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Synonyms: n.a.

What is Depakote?

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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