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Depakote and Fluoxetine

Determining the interaction of Depakote and Fluoxetine and the possibility of their joint administration.

Check result:

Depakote <> Fluoxetine

Relevance: 21.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Individual case reports suggest that fluoxetine may increase valproate levels, perhaps by inhibiting the hepatic metabolism of valproate. Another study of two patients suggests that valproate may enhance the therapeutic effects of fluoxetine. The mechanism is unknown. Patients should be monitored for altered pharmacologic effects and increased valproic acid levels if these drugs are administered concomitantly.

References

Corrigan FM "Sodium valproate augmentation of fluoxetine or fluvoxamine effects." Biol Psychiatry 31 (1992): 1178-9
Sovner R, Davis JM "A potential drug interaction between fluoxetine and valproic acid." J Clin Psychopharmacol 11 (1991): 389

Depakote

Generic Name: divalproex sodium

Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Synonyms: n.a.

What is Depakote?

Fluoxetine

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra

Synonyms: FLUoxetine

What is Fluoxetine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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