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Depakote and Primidone

Determining the interaction of Depakote and Primidone and the possibility of their joint administration.

Check result:

Depakote <> Primidone

Relevance: 21.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using primidone together with divalproex sodium may increase the effects of primidone. Contact your doctor if you experience slow or shallow breathing, blurred vision, extreme drowsiness, urinating less than usual or not at all, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Valproate may increase the plasma levels of primidone's major metabolite, phenobarbital. The mechanism may be related to decreased CYP450 hepatic metabolism of the barbiturate.

MANAGEMENT: Patients started on combination therapy should be closely monitored for clinical and laboratory evidence of toxicity. They should be advised to notify their physician if they experience excessive sedation or lethargy.

References

Wilder BJ, Willmore LJ, Bruni J, Villarreal HJ "Valproic acid: interaction with other anticonvulsant drugs." Neurology 28 (1978): 892-6
Bruni J, Wilder BJ, Perchalski RJ, Hammond EJ, Villarreal HJ "Valproic acid and plasma levels of phenobarbital." Neurology 30 (1980): 94-7
Windorfer A, Sauer W, Gadeke R "Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug." Acta Paediatr Scand 64 (1975): 771-2
Bourgeois BF "Pharmacologic interactions between valproate and other drugs." Am J Med 84 (1988): 29-33
Gram L, Wulff K, Rasmussen KE, et al "Valproate sodium: a controlled clinical trial including monitoring of drug levels." Epilepsia 18 (1977): 141-8
Patel IH, Levy RH, Cutler RE "Phenobarbital-valproic acid interaction." Clin Pharmacol Ther 27 (1980): 515-21

Depakote

Generic Name: divalproex sodium

Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Synonyms: n.a.

What is Depakote?

Primidone

Generic Name: primidone

Brand name: Mysoline

Synonyms: n.a.

What is Primidone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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