Depakote and Versacloz

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Several reports have suggested that valproate may slightly increase serum clozapine levels and levels of clozapine metabolites. Increased sedation and functional impairment may result. The mechanism of this interaction has not been delineated, but may involve competitive protein binding, which may also result in an increase in valproate concentrations. In contrast, other reports imply that valproate may induce the metabolism of clozapine which would result in a reduction in clozapine plasma levels. If clozapine and valproic acid or any of its derivatives must be used together, close observation for altered clozapine effect is recommended. The clinical significance of this potential interaction is unknown; further investigation is required.

Depakote

Generic Name: divalproex sodium

Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Synonyms: n.a.

What is Depakote?

Versacloz

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Versacloz?