Depakote Capsules and Magnesium Oxide 400
Determining the interaction of Depakote Capsules and Magnesium Oxide 400 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concurrent administration of antacids may increase the bioavailability of valproic acid. The mechanism of interaction is unknown. In seven healthy volunteers, coadministration of a single 500 mg dose of valproic acid one hour after breakfast and an antacid containing aluminum-magnesium hydroxide (dose equal to 160 mEq of neutralizing capacity) one and three hours after meals and at bedtime on the same day resulted in a mean 12% increase (range 3% to 28%) in the total area under the concentration-time curve (AUC) of valproic acid compared to administration alone. These changes are unlikely to be of clinical importance, and no special precautions appear to be necessary. Equivalent doses of antacids containing either aluminum hydroxide-magnesium trisilicate or calcium carbonate also increased the AUC of valproic acid, but the differences were not statistically significant.
- "Product Information. Depakote (divalproex sodium)." Abbott Pharmaceutical, Abbott Park, IL.
- May CA, Garnett WR, Small RE, Pellock JM "Effects of three antacids on the bioavailability of valproic acid." Clin Pharm 1 (1982): 244-7
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote
Synonyms: Depakote Sprinkles
Generic Name: magnesium oxide
Brand name: MagGel, Phillips' Cramp-free, Uro-Mag, Mag-200, Mag-Ox 400, UroMag, Mag-Oxide, Magnesium Oxide 400, MAGnesium-Oxide, Maox, Uro-Mag
Synonyms: Magnesium oxide, Magnesium Oxide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depakote Capsules-Magnesium salicylate
- Depakote Capsules-Magnesium sulfate
- Depakote Capsules-Magnesium Sulfate Granules (Epsom Salt)
- Depakote Capsules-Magnesium Sulfate in Dextrose Injection
- Depakote Capsules-Magnesium sulfate injection
- Depakote Capsules-Magnesium sulfate Oral, Topical application, Route Not Applicable
- Magnesium Oxide 400-Depakote DR
- Magnesium Oxide 400-Depakote ER
- Magnesium Oxide 400-Depakote Pellets
- Magnesium Oxide 400-Depakote Sprinkles
- Magnesium Oxide 400-Depen
- Magnesium Oxide 400-Depen Titratabs