Depakote Capsules and Norvir (Ritonavir Capsules)
Determining the interaction of Depakote Capsules and Norvir (Ritonavir Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Divalproex sodium may decrease the blood levels and effects of ritonavir. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of protease inhibitors (e.g., lopinavir, ritonavir) with valproate may result in a reduction in the plasma concentrations and therapeutic effects of valproate. The proposed mechanism may involve protease inhibitor induction of hepatic CYP450 enzymes, particularly glucuronosyltransferases, which increase metabolism of valproate. This interaction has been reported with ritonavir and ritonavir-boosted lopinavir. Data are lacking for the other protease inhibitors.
MANAGEMENT: Caution is advised if valproate is used concomitantly with the protease inhibitors ritonavir and lopinavir. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever protease inhibitors are added to or withdrawn from therapy with valproate. Patients should be monitored for loss of seizure control.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote
Synonyms: Depakote Sprinkles
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: Norvir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depakote Capsules-Norvir (Ritonavir Oral Solution)
- Depakote Capsules-Norvir (Ritonavir Powder Packets)
- Depakote Capsules-Norvir (Ritonavir Tablets)
- Depakote Capsules-Norvir Tablets
- Depakote Capsules-Norwich Aspirin
- Depakote Capsules-Nostril
- Norvir (Ritonavir Capsules)-Depakote DR
- Norvir (Ritonavir Capsules)-Depakote ER
- Norvir (Ritonavir Capsules)-Depakote Pellets
- Norvir (Ritonavir Capsules)-Depakote Sprinkles
- Norvir (Ritonavir Capsules)-Depen
- Norvir (Ritonavir Capsules)-Depen Titratabs