Depakote (Divalproex Sprinkle Capsules) and Esomeprazole Delayed-Release Tablets
Determining the interaction of Depakote (Divalproex Sprinkle Capsules) and Esomeprazole Delayed-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The coadministration of esomeprazole and drugs that are substrates of the CYP450 2C19 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to competitive inhibition of CYP450 2C19 activity by esomeprazole. The clinical significance of this potential interaction, if any, is unknown. Caution is advised if esomeprazole is used concomitantly with medications that undergo metabolism by CYP450 2C19, particularly those with a narrow therapeutic range.
- "Product Information. Nexium (esomeprazole)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: divalproex sodium
Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote
Synonyms: Depakote
Generic Name: esomeprazole
Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Esomeprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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