Depakote (Divalproex Sprinkle Capsules) and Nymalize (Nimodipine Capsules)
Determining the interaction of Depakote (Divalproex Sprinkle Capsules) and Nymalize (Nimodipine Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Valproic acid and its derivatives may increase the effects of nimodipine by decreasing first-pass metabolism and increasing bioavailability. Patients who must take both drugs should be carefully monitored for increased nimodipine effect.
- Tartara A, Galimberti CA, Manni R, et al "Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients." Br J Clin Pharmacol 32 (1991): 335-40
- Tartara A, Galimberti CA, Manni R, et al "Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients." Br J Clin Pharmacol 32 (1991): 335-40
Generic Name: divalproex sodium
Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote
Synonyms: Depakote
Generic Name: nimodipine
Brand name: Nymalize, Nimotop
Synonyms: Nymalize
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depakote (Divalproex Sprinkle Capsules)-Nymalize (Nimodipine Oral Solution)
- Depakote (Divalproex Sprinkle Capsules)-NyQuil
- Depakote (Divalproex Sprinkle Capsules)-Nyquil Cold & Flu
- Depakote (Divalproex Sprinkle Capsules)-NyQuil Cold & Flu (Alcohol Free)
- Depakote (Divalproex Sprinkle Capsules)-NyQuil Cough
- Depakote (Divalproex Sprinkle Capsules)-NyQuil D
- Nymalize (Nimodipine Capsules)-Depakote Capsules
- Nymalize (Nimodipine Capsules)-Depakote DR
- Nymalize (Nimodipine Capsules)-Depakote ER
- Nymalize (Nimodipine Capsules)-Depakote Pellets
- Nymalize (Nimodipine Capsules)-Depakote Sprinkles
- Nymalize (Nimodipine Capsules)-Depen