Depakote DR and Nitazoxanide Suspension
Determining the interaction of Depakote DR and Nitazoxanide Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nitazoxanide may increase the blood levels and effects of valproic acid. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with nitazoxanide may increase the free plasma concentrations of drugs and/or their active metabolites that are highly bound to plasma proteins. The pharmacologic effects of some drugs may be increased by this interaction. The proposed mechanism is competitive displacement from protein binding sites by tizoxanide, the active metabolite of nitazoxanide that is greater than 99.9% bound to plasma proteins.
MANAGEMENT: Caution is advised when other highly protein-bound drugs are used with nitazoxanide, particularly those with a narrow therapeutic index. Patients should be monitored more closely following the addition or withdrawal of nitazoxanide. When performing therapeutic drug monitoring, total plasma concentrations should be interpreted cautiously due to the possibility of increased free (unbound) drug.
- "Product Information. Alinia (nitazoxanide)." Romark Laboratories L.C., Tampa, FL.
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic acid, Valproic Acid and Derivatives
Generic Name: nitazoxanide
Brand name: Alinia
Synonyms: Nitazoxanide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depakote DR-Nitazoxanide Tablets
- Depakote DR-Nite-Time Cold/Flu
- Depakote DR-Nitetime Oral Liquid
- Depakote DR-Nitetime Sleep-Aid
- Depakote DR-Nithiodote
- Depakote DR-Nitisinone
- Nitazoxanide Suspension-Depakote ER
- Nitazoxanide Suspension-Depakote Pellets
- Nitazoxanide Suspension-Depakote Sprinkles
- Nitazoxanide Suspension-Depen
- Nitazoxanide Suspension-Depen Titratabs
- Nitazoxanide Suspension-Deplin