Depakote Sprinkles and Questran

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cholestyramine may interfere with the absorption of divalproex sodium and reduce its effectiveness in treating your condition. You should take cholestyramine and divalproex sodium at least 3 hours apart. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

ADJUST DOSING INTERVAL: Cholestyramine may interfere with the gastrointestinal absorption of valproic acid and reduce its bioavailability. In six study subjects, administration of a single 250 mg dose of valproic acid simultaneously with a 4 gram dose of cholestyramine (given twice daily starting one day before valproic acid administration) resulted in an average 15% decrease in valproic acid peak serum concentration and 21% decrease in systemic exposure (AUC) compared to administration alone. By contrast, no significant interaction was observed when valproic acid was given 3 hours before the cholestyramine dose. The bioavailability of valproic acid, relative to administration alone, was 86.2% when given concurrently with cholestyramine and 95.3% when given 3 hours before cholestyramine.

MANAGEMENT: To minimize potential for interaction, valproic acid and cholestyramine should be administered at least 3 hours apart. Patients should be monitored for clinical and laboratory evidence of altered valproate efficacy, and the dosage adjusted if necessary. It is not known whether these precautions are applicable to extended-release valproic acid or divalproex formulations.

Depakote Sprinkles

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote

Synonyms: Depakote Capsules

What is Depakote Sprinkles?

Questran

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: n.a.

What is Questran?