Depakote Sprinkles and Tenex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

GuanFACINE may increase the concentrations of divalproex sodium, which may lead to an increased risk of side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. You may need a change in dose or more frequent monitoring to be able to use these medicines together. Some people, especially the elderly, may also experience impairment in thinking, judgement, and motor coordination. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell you doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with guanfacine may increase plasma concentrations of valproic acid. The mechanism has not been delineated; however, it has been suggested that it may involve competitive inhibition of the glucuronidation metabolic pathway. Both valproic acid and guanfacine are metabolized by glucuronidation. Increased concentrations of valproic acid may lead to an increased risk of central nervous system (CNS) side effects. However, pharmacokinetic and clinical data are lacking.

MANAGEMENT: Caution is advised if valproic acid is used with guanfacine. Dosage adjustment as well as clinical and laboratory monitoring of valproic acid should be considered. Patients should be advised to notify their health care professional if they experience increased CNS effects, including dizziness, drowsiness, lightheadedness, confusion, or fainting.

Depakote Sprinkles

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote

Synonyms: Depakote Capsules

What is Depakote Sprinkles?

Tenex

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: n.a.

What is Tenex?