Depo-Medrol injection and Diastat Pediatric
Determining the interaction of Depo-Medrol injection and Diastat Pediatric and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. Limited data are available for midazolam and triazolam. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of dexamethasone on the pharmacokinetics of triazolam." Pharmacol Toxicol 83 (1998): 135-8
- Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y "Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans." Ther Drug Monit 21 (1999): 507-13
Generic Name: methylprednisolone
Brand name: A-methapred, Depo-Medrol, Solu-Medrol, Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack
Synonyms: Depo-Medrol (injection), Depo-Medrol
Generic Name: diazepam
Brand name: Diastat AcuDial, Diastat Pediatric, Diastat, Valium, Diazepam Intensol, Zetran
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Depo-Medrol injection-Diatrizoate Injection
- Depo-Medrol injection-Diatrizoate Meglumine
- Depo-Medrol injection-Diatrizoate Meglumine and Diatrizoate Sodium
- Depo-Medrol injection-Diatrizoate Meglumine and Iodipamide Meglumine
- Depo-Medrol injection-Diatx Zn
- Depo-Medrol injection-Diazepam
- Diastat Pediatric-Depo-Provera
- Diastat Pediatric-Depo-Provera (Medroxyprogesterone Injection (400 mg/mL))
- Diastat Pediatric-Depo-Provera (Medroxyprogesterone Injection (Intramuscular))
- Diastat Pediatric-Depo-Provera Contraceptive
- Diastat Pediatric-Depo-Provera Contraceptive injection
- Diastat Pediatric-Depo-Provera injection