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Depo-subQ provera 104 and Tamoxifen Solution

Determining the interaction of Depo-subQ provera 104 and Tamoxifen Solution and the possibility of their joint administration.

Check result:
Depo-subQ provera 104 <> Tamoxifen Solution
Relevance: 02.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that concomitant administration of medroxyprogesterone may reduce N-demethylation of tamoxifen, but that overall metabolism remains unchanged. The mechanism and the clinical significance of this interaction are unknown.

References
  • Reid AD, Horobin JM, Newman EL, Preece PE "Tamoxifen metabolism is altered by simultaneous administration of medroxyprogesterone acetate in breast cancer patients." Breast Cancer Res Treat 22 (1992): 153-6
Depo-subQ provera 104

Generic Name: medroxyprogesterone

Brand name: Depo-Provera, Depo-Provera Contraceptive, Depo-subQ provera 104, Provera

Synonyms: Depo-SubQ Provera 104 (injection), Depo-SubQ Provera 104

Tamoxifen Solution

Generic Name: tamoxifen

Brand name: Soltamox, Nolvadex

Synonyms: Tamoxifen

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle