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DepoDur and Zyvox (Linezolid Suspension)

Determining the interaction of DepoDur and Zyvox (Linezolid Suspension) and the possibility of their joint administration.

Check result:

DepoDur <> Zyvox (Linezolid Suspension)

Relevance: 21.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using linezolid together with morphine liposomal. Using these medications together can increase the blood levels or add to the side effects of morphine liposomal. This cans cause extreme drowsiness, pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or even coma. You should wait 14 days after stopping an MAOI before you start using morphine liposomal. You may need a dose adjustment if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Monoamine oxidase inhibitors (MAOIs) markedly potentiate the action of morphine. Coadministration of narcotic analgesics including morphine in patients treated with MAOIs has rarely resulted in hypotension, respiratory depression, or coma. The mechanism is unknown but may be related to additive central nervous system and respiratory depressant effects.

MANAGEMENT: Morphine liposomal preparations should not be used in patients taking MAOIs or other agents which possess MAOI activity (e.g., furazolidone, procarbazine, selegiline), or within 14 days of stopping such treatment.

References

Garbutt JC "Potentiation of propoxyphene by phenelzine." Am J Psychiatry 144 (1987): 251-2
Evans-Prosser CD "The use of pethidine and morphine in the presence of monoamine oxidase inhibitors." Br J Anaesth 40 (1968): 279-82
Zornberg GL, Hegarty JD "Adverse interaction between propoxyphene and phenelzine." Am J Psychiatry 150 (1993): 1270-1
Browne B, Linter S "Monoamine oxidase inhibitors and narcotic analgesics: a critical review of the implications for treatment." Br J Psychiatry 151 (1987): 210-2
Michaels I, Serrins M, Shier NQ, Barash PG "Anesthesia for cardiac surgery in patients receiving monoamine oxidase inhibitors." Anesth Analg 63 (1984): 1041-4
"Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.

DepoDur

Generic Name: morphine liposomal

Brand name:

Synonyms: n.a.

What is DepoDur?

Zyvox (Linezolid Suspension)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Suspension)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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