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Deprizine FusePaq and Nifedical XL

Determining the interaction of Deprizine FusePaq and Nifedical XL and the possibility of their joint administration.

Check result:

Deprizine FusePaq <> Nifedical XL

Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The plasma concentration of some calcium channel blockers may be increased by H2 blockers such as cimetidine and ranitidine. The mechanism is related to inhibition of liver cytochrome P450 enzymes responsible for metabolism and/or increased gastric pH. Ranitidine is a much weaker inhibitor of the cytochrome P450 system and effects are not expected to be clinically significant. Other H2 blockers, antacids, and proton pump inhibitors that notably increase gastric pH would be expected to have a similar effect. Clinical monitoring of patient response and tolerance is recommended and calcium channel blocker dosage adjustments may be indicated.

References

"Product Information. Tagamet (cimetidine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.

Deprizine FusePaq

Generic Name: ranitidine

Brand name: Zantac

Synonyms: Ranitidine

What is Deprizine FusePaq?

Nifedical XL

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: Nifedical XL (Oral)

What is Nifedical XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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