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Desflurane and EpiPen JR 2-Pak

Determining the interaction of Desflurane and EpiPen JR 2-Pak and the possibility of their joint administration.

Check result:

Desflurane <> EpiPen JR 2-Pak

Relevance: 25.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using EPINEPHrine together with desflurane. Taking these drugs together can affect the rhythm of your heart. This can cause symptoms of irregular heartbeat, chest tightness, blurred vision, nausea, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Rarely, the combination of epinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated anesthetics sensitize the heart to the arrhythmogenic effects of catecholamines.

MANAGEMENT: This combination should be avoided or used very cautiously. If a halogenated anesthetic and epinephrine must be used together, an epinephrine concentration of 1:100,000 or 1:200,000 is recommended. The adult dosage should not exceed 100 mcg of a 1:100,000 solution in any 10-minute period. The patient's hemodynamic status should be closely monitored. Lidocaine has a protective effect against the arrhythmogenic potential of epinephrine. Topical epinephrine appears to be relatively safe for use during anesthesia.

References

Karl HW, Swedlow DB, Lee KW, Downes JJ "Epinephrine-halothane interactions in children." Anesthesiology 58 (1983): 142-5
"Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.
Reisner LS, Lippmann M "Further data on epinephrine interactions." Anesth Analg 56 (1977): 468
Konchigeri HN, Shaker MH, Winnie AP "Effect of epinephrine during enflurane anesthesia." Anesth Analg 53 (1974): 894-7
Ghoneim MM "Drug interaction in anaesthesia. A review." Can Anaesth Soc J 18 (1971): 353-75
Ueda W, Hirakawa M, Mae O "Appraisal of epinephrine administration to patients under halothane anesthesia for closure of cleft palate." Anesthesiology 58 (1983): 574-6
Forbes AM "Halothane, adrenaline and cardiac arrest." Anaesthesia 21 (1966): 22-7
Mostello L, Stueber K, Lake CR "Is topical application of epinephrine at skin graft donor sites during halothane anesthesia safe?" Ann Plast Surg 20 (1988): 313-6
Cullen BF, Miller MG "Drug interactions and anesthesia: a review." Anesth Analg 58 (1979): 413-23
Johnston RR, Eger EI II, Wilson C "A comparative interaction of epinephrine with enflurane, isoflurane, and halothane in man." Anesth Analg 55 (1976): 709-12
Hirshom WI, Taylor RG, Sheehan JC "Arrhythmias produced by combinations of halothane and small amounts of vasopressor." Br J Oral Surg 2 (1964): 131-6
Cooke JE "Drug interactions in anesthesia." Clin Plast Surg 12 (1985): 83-9
Smith RB "Drug interactions and drug reactions." Otolaryngol Clin North Am 14 (1981): 615-29
Reisner LS, Lippmann M "Ventricular arrhythmias after epinephrine injection in enflurane and in halothane anesthesia." Anesth Analg 54 (1975): 468-70
Horrigan RW, Eger EI, Wilson C "Epinephrine-induced arrhythmias during enflurane anesthesia in man: a nonlinear dose-response relationship and dose-dependent protection from lidocaine." Anesth Analg 57 (1978): 547-50
Bennett JA, Eltringham RJ "Possible dangers of anaesthesia in patients receiving fenfluramine. Results of animal studies following a case of human cardiac arrest." Anaesthesia 32 (1977): 8-13
Snow JC, Shamsai J, Sakarya I "Effects of epinephrine during halothane anesthesia in mastoidotympanoplastic surgery." Anesth Analg 47 (1968): 252-6
Pepple J "Epinephrine-halothane interaction in children versus adults." Anesthesiology 60 (1984): 76-8
"Product Information. Fluothane (halothane)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Kainuma M, Suzuki A "Convulsions after adrenaline administration during enflurane anaesthesia." Anaesthesia 41 (1986): 874-5

Desflurane

Generic Name: desflurane

Brand name: Suprane

Synonyms: Desflurane Liquid

What is Desflurane?

EpiPen JR 2-Pak

Generic Name: epinephrine

Brand name: Adrenalin, Auvi-Q, Epinephrinesnap-EMS, EpiPen 2-Pak, EpiPen JR 2-Pak, EPIsnap, Symjepi, Auvi-Q Auto-injector, Primatene Mist Inhaler, Adrenaclick, EpiPen, Twinject, Primatene Mist

Synonyms: n.a.

What is EpiPen JR 2-Pak?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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