Desipramine Hydrochloride and Lenalidomide

• Generic Name: desipramine
• Dosage Forms: n.a.
• Other Brand Names: Norpramin

Management of major depressive disorder.

Results of several studies of TCAs in preadolescent and adolescent patients with major depression indicate lack of overall efficacy in this age group.

Has been used for the management of panic disorder with or without agoraphobia.

Has been used for the management of eating disorders (e.g., bulimia, anorexia nervosa) with equivocal results; avoid use in underweight individuals and in those exhibiting suicidal ideation.

Has been used for the short-term management of acute depressive episodes in bipolar disorder.

TCAs associated with a greater risk of precipitating hypomania or manic episodes than other classes of antidepressants; should always be used in combination with a mood stabilizer (e.g., lithium).

Has been used for the management of acute depressive episodes (in combination with an antipsychotic) in patients with schizophrenia.

Among the drugs of choice for the symptomatic treatment of postherpetic neuralgia.

Less effective for insomnia and associated with more serious adverse reactions than conventional hypnotics.

Not recommended for use in children with ADHD. (See Pediatric Use under Cautions.)

• Generic Name: lenalidomide
• Dosage Forms: n.a.
• Other Brand Names: Revlimid

Lenalidomide is used to treat multiple myeloma (bone marrow cancer), either in combination with another medicine or after stem cell transplant.

Lenalidomide is also used to treat anemia (a lack of red blood cells) in patients with myelodysplastic syndrome caused by an abnormal chromosome. This disorder is also called deletion 5q MDS, because part of chromosome 5 is missing. In people with this disorder, the bone marrow does not produce enough healthy blood cells.

Lenalidomide is also used to treat mantle cell lymphoma, follicular lymphoma, or marginal zone lymphoma, after other medications have been tried without success.

Lenalidomide is available only under a special program. You must be registered in the program and understand the risks and benefits of lenalidomide. You must also agree to use birth control measures as required by the program.

Lenalidomide may also be used for purposes not listed in this medication guide.