Desipramine Hydrochloride and Meclofenamate Sodium

• Generic Name: desipramine
• Dosage Forms: n.a.
• Other Brand Names: Norpramin

Management of major depressive disorder.

Results of several studies of TCAs in preadolescent and adolescent patients with major depression indicate lack of overall efficacy in this age group.

Has been used for the management of panic disorder with or without agoraphobia.

Has been used for the management of eating disorders (e.g., bulimia, anorexia nervosa) with equivocal results; avoid use in underweight individuals and in those exhibiting suicidal ideation.

Has been used for the short-term management of acute depressive episodes in bipolar disorder.

TCAs associated with a greater risk of precipitating hypomania or manic episodes than other classes of antidepressants; should always be used in combination with a mood stabilizer (e.g., lithium).

Has been used for the management of acute depressive episodes (in combination with an antipsychotic) in patients with schizophrenia.

Among the drugs of choice for the symptomatic treatment of postherpetic neuralgia.

Less effective for insomnia and associated with more serious adverse reactions than conventional hypnotics.

Not recommended for use in children with ADHD. (See Pediatric Use under Cautions.)

• Generic Name: meclofenamate
• Dosage Forms: n.a.
• Other Brand Names:

  Meclomen

Consider potential benefits and risks of meclofenamate sodium therapy as well as alternative therapies before initiating therapy with the drug. Use lowest effective dosage and shortest duration of therapy consistent with the patient’s treatment goals.

Symptomatic treatment of acute and chronic osteoarthritis and rheumatoid arthritis.

Has been used with some success in a limited number of adults with ankylosing spondylitis or acute gouty arthritis.

Has been used in a limited number of patients with psoriatic arthritis.

Relief of mild to moderate pain in adults.

Treatment of primary dysmenorrhea.

Treatment of idiopathic menorrhagia. Use only for heavy menstrual flow that is idiopathic (i.e., no underlying pathophysiologic cause can be identified); do not use for the management of spotting or bleeding that occurs between menstrual cycles.

Use for primary dysmenorrhea or idiopathic menorrhagia only when the potential benefits justify the possible risks.