Desipramine Hydrochloride and Mipomersen

• Generic Name: desipramine
• Dosage Forms: n.a.
• Other Brand Names: Norpramin

Management of major depressive disorder.

Results of several studies of TCAs in preadolescent and adolescent patients with major depression indicate lack of overall efficacy in this age group.

Has been used for the management of panic disorder with or without agoraphobia.

Has been used for the management of eating disorders (e.g., bulimia, anorexia nervosa) with equivocal results; avoid use in underweight individuals and in those exhibiting suicidal ideation.

Has been used for the short-term management of acute depressive episodes in bipolar disorder.

TCAs associated with a greater risk of precipitating hypomania or manic episodes than other classes of antidepressants; should always be used in combination with a mood stabilizer (e.g., lithium).

Has been used for the management of acute depressive episodes (in combination with an antipsychotic) in patients with schizophrenia.

Among the drugs of choice for the symptomatic treatment of postherpetic neuralgia.

Less effective for insomnia and associated with more serious adverse reactions than conventional hypnotics.

Not recommended for use in children with ADHD. (See Pediatric Use under Cautions.)

• Generic Name: mipomersen
• Dosage Forms: n.a.
• Other Brand Names: Kynamro

Mipomersen is a cholesterol-lowering medication. It reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL), apolipoprotein-B (apo-B), or non-high-density lipoprotein (non-HDL).

Mipomersen is used together with a low-fat diet and other treatments to lower total cholesterol in people with homozygous familial hypercholesterolemia (an inherited type of high cholesterol). Mipomersen is not for use in people with heterozygous familial hypercholesterolemia.

It is not known whether mipomersen will lower your risk of heart disease.

Mipomersen is available only from a certified pharmacy under a special program called Kynamro REMS. Your doctor must be registered in the program in order to prescribe mipomersen for you.

Mipomersen may also be used for purposes not listed in this medication guide.