Desipramine Hydrochloride and Verapamil oral/injection
Determining the interaction of Desipramine Hydrochloride and Verapamil oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use desipramine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase the effects of desipramine. You should notify your doctor if you have symptoms of dry mouth, blurry vision, irregular or fast heartbeat, constipation, urine retention, dizziness, or a drop in blood pressure that is brought on by changes in body position. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Concurrent administration of verapamil may increase tricyclic antidepressant (TCA) serum concentrations. The mechanism appears to be inhibition of CYP450 metabolism. Pharmacologic and toxic effects of TCAs may be increased.
MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever verapamil is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Dose adjustments may be necessary.
- Hermann DJ, Krol TF, Dukes GE, et al "Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine." J Clin Pharmacol 32 (1992): 176-83
- "Product Information. Calan (verapamil)." Searle, Skokie, IL.
Generic Name: desipramine
Brand name: Norpramin
Synonyms: Desipramine
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Desipramine Hydrochloride-Verapamil Sustained-Release Capsules
- Desipramine Hydrochloride-Verdeso
- Desipramine Hydrochloride-Verdrocet
- Desipramine Hydrochloride-Verelan
- Desipramine Hydrochloride-Verelan PM
- Desipramine Hydrochloride-Veripred 20
- Verapamil oral/injection-Desirudin
- Verapamil oral/injection-Desirudin Subcutaneous
- Verapamil oral/injection-Desloratadine
- Verapamil oral/injection-Desloratadine and pseudoephedrine
- Verapamil oral/injection-Desloratadine Oral Solution
- Verapamil oral/injection-Desloratadine Orally Disintegrating Tablets