Desmopressin Nasal, Oral, Injection and Trametinib

• Generic Name: desmopressin
• Dosage Forms: n.a.
• Other Brand Names: DDAVP, Nocdurna, DDAVP nasal, DDAVP Rhinal Tube, Noctiva, Stimate

Desmopressin nasal spray is used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated. It is also used to control frequent urination and increased thirst caused by certain types of brain injury or brain surgery. The Stimate® nasal spray is used to treat bleeding in patients with hemophilia A or von Willebrand disease (Type I).

Noctiva™ nasal spray is used to treat nocturnal polyuria in adults who awaken two or more times to urinate at night. Nocturnal polyuria is a condition where your body makes too much urine at night. Your doctor will need to measure your urine and the times that you urinate for 24 hours to determine if you have nocturnal polyuria.

Desmopressin is similar to a hormone that is produced in the body. It acts on the kidneys to reduce the flow of urine. For bleeding, desmopressin increases the blood levels of factor VIII and von Willebrand factor. This results in less bleeding for patients who have low levels of these agents.

Desmopressin is available only with your doctor's prescription.

• Generic Name: trametinib
• Dosage Forms: n.a.
• Other Brand Names: Mekinist

Trametinib is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation. These medicines are for use in treating:

• melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;

• non-small cell lung cancer that has spread to other parts of the body; or

• advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.

Trametinib may also be used for purposes not listed in this medication guide.