Desogestrel and ethinyl estradiol and Diastat AcuDial
Determining the interaction of Desogestrel and ethinyl estradiol and Diastat AcuDial and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral contraceptives may prolong the half-life of certain benzodiazepines that undergo hepatic oxidative metabolism (such as diazepam and chlordiazepoxide). Other benzodiazepines also may participate in this interaction. Close observation for signs and symptoms of altered benzodiazepine effect is recommended.
- Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB "Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics." Clin Pharmacol Ther 36 (1984): 683-90
- Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI "Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids." N Engl J Med 306 (1982): 791-2
- Patwardhan RV, Mitchell MC, Johnson RF, Schenker S "Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines." Hepatology 3 (1983): 248-53
- Scavone JM, Greenblatt DJ, Locniskar A, Shader RI "Alprazolam pharmacokinetics in women on low-dose oral contraceptives." J Clin Pharmacol 28 (1988): 454-7
Generic Name: desogestrel / ethinyl estradiol
Brand name: Azurette, Cyclessa, Desogen, Isibloom, Kariva, Mircette, Reclipsen, Cyred
Synonyms: Ethinyl estradiol and desogestrel, Ethinyl Estradiol and Desogestrel
Generic Name: diazepam
Brand name: Diastat AcuDial, Diastat Pediatric, Diastat, Valium, Diazepam Intensol, Zetran
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Desogestrel and ethinyl estradiol-Diastat Pediatric
- Desogestrel and ethinyl estradiol-Diatrizoate Injection
- Desogestrel and ethinyl estradiol-Diatrizoate Meglumine
- Desogestrel and ethinyl estradiol-Diatrizoate Meglumine and Diatrizoate Sodium
- Desogestrel and ethinyl estradiol-Diatrizoate Meglumine and Iodipamide Meglumine
- Desogestrel and ethinyl estradiol-Diatx Zn
- Diastat AcuDial-Desonate
- Diastat AcuDial-Desonide
- Diastat AcuDial-Desonide Cream
- Diastat AcuDial-Desonide Cream, Gel, and Ointment
- Diastat AcuDial-Desonide Foam
- Diastat AcuDial-Desonide Lotion