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Despec-SR and VoSpire ER

Determining the interaction of Despec-SR and VoSpire ER and the possibility of their joint administration.

Check result:

Despec-SR <> VoSpire ER

Relevance: 18.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using albuterol together with pseudoephedrine may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists can produce clinically significant cardiovascular effects including increases in pulse rate and systolic or diastolic blood pressure as well as ECG changes such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The risk is lower when beta-2 adrenergic agonists are inhaled at normally recommended dosages. However, these effects may be more common when the drugs are administered systemically or when recommended dosages are exceeded.

MANAGEMENT: Caution is advised if beta-2 adrenergic agonists are used concomitantly with other adrenergic agents, particularly in patients with cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, hypertrophic obstructive cardiomyopathy, or hypertension. Blood pressure and heart rate should be closely monitored.

References

"Product Information. Proventil (albuterol)." Schering Laboratories, Kenilworth, NJ.
Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9
"Product Information. Foradil (formoterol)" Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Striverdi Respimat (olodaterol)." Boehringer Ingelheim, Ridgefield, CT.
Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51
"Product Information. Severent (salmeterol)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Xopenex (levalbuterol)." Sepracor, Marlborough, MA.
"Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals, St. Paul, MN.
"Product Information. Arcapta Neohaler (indacaterol)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Brovana (arformoterol)." Sepracor Inc, Marlborough, MA.
"Product Information. Breo Ellipta (fluticasone-vilanterol)." GlaxoSmithKline, Research Triangle Park, NC.

Despec-SR

Generic Name: guaifenesin / pseudoephedrine

Brand name: Ambifed-G, Despec-SR, Entex T, Maxifed, Mucinex D, Mucinex D Max Strength, Poly-Vent IR, Respaire-30, Robitussin Severe Congestion, Sinutab Non Drying, Triaminic Softchews Chest Congestion, Tusnel Pediatric Drops, Entex PSE, Zephrex LA, Guaimax-D, Anatuss LA, Touro LA, Medent, Fenex-PSE, Nalex, Syn-Rx, Rymed, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Guaifed-PD, Pseudocot-G, Zephrex, Nasatab LA, Eudal SR, Medent LD, Sudal 60/500, Maxifed-G, Tuss-LA, Stamoist E, V-Dec-M, Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Guiatex II, Guiadrine II SR, Defen-LA, Respa-1st, Decongest II, Desal II, Deco-D, GP 500, Guaifed-PSE, Pan-Mist LA, Abletex-PSE, Guiadrine PSE 120, Duratuss, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Ru Tuss DE, Robitussin PE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Pseudoephedrine-GuaiFENesin, Robafen PE, Guaivent, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Congestac, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Duratuss GP, Aquatab D, Guaifenex GP, Dynex, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, Triaminic Chest Congestion, Coldmist, Aquatab D Dose Pack, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Levall G, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Guaifenex PSE 85, Poly-Vent, Jr, Nomuc-PE, Ambi 60/580, Ambi 80/780, Ambi 60/1000, Pseudo GG TR, Ru-Tuss Jr, ExeFen, SudaTex-G, Medent-LDI, Ambifed, Tenar PSE, ExeFen-IR, Mucus Relief D, Mardrops-EX, Triaminic Chest/Nasal

Synonyms: n.a.

What is Despec-SR?

VoSpire ER

Generic Name: albuterol

Brand name: Proventil, VoSpire ER, ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA, Accuneb, ProAir Digihaler

Synonyms: n.a.

What is VoSpire ER?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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