Desyrel and Incivek

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Telaprevir may increase the blood levels and effects of traZODone. This can increase the risk of side effects such as nausea, dizziness, and low blood pressure. You may need a dose adjustment or frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: According to the product information for the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, plasma concentrations of the antidepressants desipramine and trazodone may be increased when coadministered with these agents. The mechanism may involve inhibition of CYP450 3A4 metabolism. No pharmacokinetic data are currently available; however, adverse effects such as nausea, dizziness, hypotension, and syncope may be increased.

MANAGEMENT: Caution is advised if desipramine or trazodone is used in combination with HCV NS3/4A protease inhibitors. A lower dosage of the antidepressant should be considered.

Desyrel

Generic Name: trazodone

Brand name: Desyrel, Oleptro, Desyrel Dividose

Synonyms: n.a.

What is Desyrel?

Incivek

Generic Name: telaprevir

Brand name: Incivek

Synonyms: n.a.

What is Incivek?