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Desyrel and Prilosec (Omeprazole Delayed-Release Capsules)

Determining the interaction of Desyrel and Prilosec (Omeprazole Delayed-Release Capsules) and the possibility of their joint administration.

Check result:

Desyrel <> Prilosec (Omeprazole Delayed-Release Capsules)

Relevance: 28.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

An interaction with omeprazole was suggested as the cause of trazodone toxicity in a patient who experienced lightheadedness and syncope while receiving the combination. In an isolated case report, a 54-year-old patient receiving trazodone (50 mg/day), omeprazole (20 mg/day), and simvastatin (20 mg/day) developed second degree Mobitz type 1 atrioventricular block, which the authors speculated was due to trazodone toxicity stemming from inhibition of its metabolism by omeprazole. However, causality is difficult to establish in this particular case due to potential confounding factors and lack of details. Trazodone is primarily metabolized by CYP450 3A4, yet omeprazole is not known to be a significant in vivo inhibitor of the isoenzyme. In addition, the patient had doubled the dose of trazodone on his own the night before presentation to the emergency room. There were also no rechallenge or dechallenge information provided in the report, nor blood levels of trazodone indicating toxicity. The patient recovered following discontinuation of both omeprazole and trazodone.

References

Tateishi T, Graham SG, Krivoruk Y, Wood AJ "Omeprazole does not affect measured CYP3A4 activity using the erythromycin breath test" Br J Clin Pharmacol 40 (1995): 411-2
Akinseye OA, Alfishawy M, Radparvar F, Bakshi S "Trazodone and omeprazole interaction causing frequent second-degree Mobitz type 1 atrioventricular (AV) block (Wenckebach phenomenon) and syncope: a case report and literature review." Am J Case Rep 16 (2015): 319-21
"Product Information. Oleptro (traZODone)." Labopharm Inc, Laval, AL.

Desyrel

Generic Name: trazodone

Brand name: Desyrel, Oleptro, Desyrel Dividose

Synonyms: n.a.

What is Desyrel?

Prilosec (Omeprazole Delayed-Release Capsules)

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Prilosec, Prilosec OTC, Zegerid>

Synonyms: Prilosec

What is Prilosec (Omeprazole Delayed-Release Capsules)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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