Dexamethasone and Netupitant and Palonosetron Hydrochloride
Determining the interaction of Dexamethasone and Netupitant and Palonosetron Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Netupitant may increase the blood levels and effect of dexamethasone. This should not be a concern if you are receiving dexamethasone in combination with netupitant for the prevention of nausea and vomiting associated with cancer chemotherapy, since the dosage of dexamethasone recommended in this regimen already takes into account the interaction. If you are receiving dexamethasone therapy for more than a few days for some other medical reason, you may experience a short-term increase of dexamethasone side effects for about a week after a single dose of netupitant. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with netupitant or its prodrug, fosnetupitant, may significantly increase the plasma concentrations of dexamethasone. The proposed mechanism is netupitant inhibition of dexamethasone metabolism via CYP450 3A4. When a single 300 mg dose of netupitant was coadministered with a dexamethasone regimen consisting of 20 mg on day 1, followed by 8 mg twice daily from days 2 to Day 4, mean dexamethasone systemic exposure (AUC) was increased by 1.7-fold on day 1 and up to 2.4-fold on day 2 and day 4. The duration of the effect was not studied beyond 4 days.
MANAGEMENT: Dexamethasone should be administered at a reduced dosage when used with netupitant or fosnetupitant. For the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, dexamethasone should be dosed according to the product labeling for netupitant-palonosetron or fosnetupitant-palonosetron.
- "Product Information. Akynzeo (netupitant-palonosetron)." Eisai Inc, Woodcliff Lake, NJ.
- "Product Information. Akynzeo for Injection (fosnetupitant-palonosetron)." Helsinn Therapeutics Inc, Woodbridge Township, NJ.
Generic Name: dexamethasone
Brand name: Baycadron, Decadron, Dexamethasone Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA
Synonyms: Dexamethasone (Systemic)
Generic Name: netupitant / palonosetron
Brand name: Akynzeo
Synonyms: Netupitant and palonosetron, Netupitant and Palonosetron
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexamethasone-Neuac
- Dexamethasone-Neuac Gel
- Dexamethasone-Neuac Kit
- Dexamethasone-Neulasta
- Dexamethasone-Neulasta Delivery Kit
- Dexamethasone-Neulasta Onpro Kit
- Netupitant and Palonosetron Hydrochloride-Dexamethasone (Systemic)
- Netupitant and Palonosetron Hydrochloride-Dexamethasone and tobramycin ophthalmic
- Netupitant and Palonosetron Hydrochloride-Dexamethasone Elixir
- Netupitant and Palonosetron Hydrochloride-Dexamethasone Elixir and Solution
- Netupitant and Palonosetron Hydrochloride-Dexamethasone Eye Drops (Suspension)
- Netupitant and Palonosetron Hydrochloride-Dexamethasone Eye Implant and Insert