Dexamethasone Injection Solution and Prograf (Tacrolimus Capsules)
Determining the interaction of Dexamethasone Injection Solution and Prograf (Tacrolimus Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of tacrolimus in some patients, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of sirolimus and tacrolimus, both of which are primarily metabolized by the isoenzyme.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant drug levels, caution is advised during concomitant therapy with CYP450 3A4 inducers. Sirolimus and tacrolimus blood levels should be checked frequently and the dosage adjusted accordingly whenever a CYP450 3A4 inducer is added to or withdrawn from therapy.
- "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: dexamethasone
Brand name: Baycadron, Decadron, Dexamethasone Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA
Synonyms: Dexamethasone, Dexamethasone (Systemic)
Generic Name: tacrolimus
Brand name: Prograf, Astagraf XL, Envarsus XR, Hecoria
Synonyms: Prograf
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexamethasone Injection Solution-Prograf (Tacrolimus Granules for Suspension)
- Dexamethasone Injection Solution-Prograf (Tacrolimus Injection)
- Dexamethasone Injection Solution-Prograf Intravenous
- Dexamethasone Injection Solution-Prohance
- Dexamethasone Injection Solution-ProHance Injection
- Dexamethasone Injection Solution-Prohist LQ
- Prograf (Tacrolimus Capsules)-Dexamethasone Intensol
- Prograf (Tacrolimus Capsules)-Dexamethasone intraocular
- Prograf (Tacrolimus Capsules)-Dexamethasone ophthalmic
- Prograf (Tacrolimus Capsules)-Dexamethasone Oral Drops
- Prograf (Tacrolimus Capsules)-Dexamethasone SodiumPhosphate
- Prograf (Tacrolimus Capsules)-Dexamethasone Solution (Drops)