Dexamethasone Oral Drops and Sustiva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using efavirenz together with dexamethasone may alter the blood levels and effects of both medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your conditions worsen or you experience new or increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of efavirenz with a drug that is both a substrate as well as inducer of CYP450 3A4 may result in altered plasma concentrations of both drugs. Efavirenz itself is also a substrate and inducer of CYP450 3A4. Theoretically, metabolism of efavirenz and the coadministered drug may be mutually induced when used in combination. Alternatively, competitive inhibition of CYP450 3A4 may occur, which can lead to increased plasma drug levels of one or both drugs. The interaction has not been specifically studied.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if efavirenz is prescribed in combination with a drug that is an inducer of CYP450 3A4. Close clinical and laboratory monitoring of antiretroviral response is recommended. In addition, dosage adjustments may be required for the coadministered drug if it is also a substrate of CYP450 3A4.

Dexamethasone Oral Drops

Generic Name: dexamethasone

Brand name: Baycadron, Decadron, Dexamethasone Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA

Synonyms: Dexamethasone, Dexamethasone (Systemic)

What is Dexamethasone Oral Drops?

Sustiva

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Sustiva?