Dexasone injection and Panobinostat Lactate
Determining the interaction of Dexasone injection and Panobinostat Lactate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of panobinostat. In some cases, this may make the medication less effective. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of panobinostat, which is partially metabolized by the isoenzyme. The interaction has not been evaluated clinically, but simulations using physiologically-based pharmacokinetic (PBPK) models suggest an approximately 70% decrease in panobinostat systemic exposure in the presence of potent CYP450 3A4 inducers.
MANAGEMENT: Caution is advised during concomitant use of panobinostat with CYP450 3A4 inducers. The potential for decreased efficacy of panobinostat should be considered.
- "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: dexamethasone
Brand name: De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: Dexasone (injection)
Generic Name: panobinostat
Brand name: Farydak
Synonyms: Panobinostat
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexasone injection-Panocaps
- Dexasone injection-PanOxyl
- Dexasone injection-Panoxyl Soap
- Dexasone injection-PanOxyl Wash
- Dexasone injection-PanOxyl-4 Creamy Wash
- Dexasone injection-PanOxyl-8 Creamy Wash
- Panobinostat Lactate-Dexasone LA injection
- Panobinostat Lactate-Dexbrompheniramine
- Panobinostat Lactate-Dexbrompheniramine and Acetaminophen Caplets
- Panobinostat Lactate-Dexbrompheniramine and phenylephrine
- Panobinostat Lactate-Dexbrompheniramine and Phenylephrine Syrup
- Panobinostat Lactate-Dexbrompheniramine and Phenylephrine Tablets