Dexasone LA injection and Metoprolol Extended-Release Capsules
Determining the interaction of Dexasone LA injection and Metoprolol Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the effects of metoprolol in lowering blood pressure. The interaction is most likely to occur when dexamethasone is used for more than a week, since prolonged use can cause sodium and water retention. Let your doctor know if you experience sudden, unexplained weight gain or swelling of the hands, ankles, or feet. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the natural corticosteroids (cortisone, hydrocortisone) because they have greater mineralocorticoid activity. Conversely, some calcium channel blockers such as diltiazem and verapamil may increase corticosteroid plasma levels and effects by inhibiting their clearance via CYP450 3A4 metabolism.
MANAGEMENT: Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.
- "Multum Information Services, Inc. Expert Review Panel"
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: dexamethasone
Brand name: De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: Dexasone LA (injection)
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexasone LA injection-Metoprolol Extended-Release Tablets
- Dexasone LA injection-Metoprolol Injection
- Dexasone LA injection-Metoprolol Intravenous
- Dexasone LA injection-Metoprolol Succinate
- Dexasone LA injection-Metoprolol Succinate ER Capsules
- Dexasone LA injection-Metoprolol Succinate ER Tablets
- Metoprolol Extended-Release Capsules-Dexbrompheniramine
- Metoprolol Extended-Release Capsules-Dexbrompheniramine and Acetaminophen Caplets
- Metoprolol Extended-Release Capsules-Dexbrompheniramine and phenylephrine
- Metoprolol Extended-Release Capsules-Dexbrompheniramine and Phenylephrine Syrup
- Metoprolol Extended-Release Capsules-Dexbrompheniramine and Phenylephrine Tablets
- Metoprolol Extended-Release Capsules-Dexbrompheniramine and pseudoephedrine