Dexasone LA injection and Vecuronium Bromide
Determining the interaction of Dexasone LA injection and Vecuronium Bromide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may alter the effects of vecuronium. In addition, there may be an increased risk of developing muscle disorders if these agents are used together for prolonged periods. Close monitoring is required. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Corticosteroids may inhibit or enhance the action of nondepolarizing skeletal muscle relaxants. The mechanism is unknown. In addition, the risk of myopathy may be increased after long-term use of neuromuscular blocking agents and corticosteroids.
MANAGEMENT: Patients should be closely monitored for altered neuromuscular blockade and signs of myopathy. Dose adjustments of the muscle relaxant may be required. The benefit-to-risk ratio should be considered and the duration of administration of the neuromuscular blocking agent should be limited as much as clinically feasible.
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- "Product Information. Norcuron (vecuronium)." Organon, West Orange, NJ.
- Laflin MJ "Interaction of pancuronium and corticosteroids." Anesthesiology 47 (1977): 471-2
- Parr SM, Galletly DC, Robinson BJ "Betamethasone-induced resistance to vercuronium: a potential problem in neurosurgery." Anaesth Intensive Care 19 (1991): 103-5
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Zemuron (rocuronium)." Organon, West Orange, NJ.
- Meyers EF "Partial recovery from pancuronium neuromuscular blockade following hydrocortosone administration." Anesthesiology 46 (1977): 148-50
Generic Name: dexamethasone
Brand name: De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: Dexasone LA (injection)
Generic Name: vecuronium
Brand name: Vecuronium Bromide, Norcuron
Synonyms: Vecuronium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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