Dexmedetomidine hydrochloride Injection, Concentrate and Sacubitril and valsartan
Determining the interaction of Dexmedetomidine hydrochloride Injection, Concentrate and Sacubitril and valsartan and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexmedetomidine can lower blood pressure and slow the heart rate, and combining it with valsartan may add to these effects. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Dexmedetomidine has been associated with hypotensive and negative chronotropic effects. Coadministration with other agents causing these effects, especially vasodilators and alpha-2 agonists, may result in additive effects on blood pressure and heart rate. Data have been conflicting. Additive pharmacodynamic effects were not observed in some clinical studies.
MANAGEMENT: Caution and monitoring of the patient's hemodynamic status are recommended during coadministration.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Precedex (dexmedetomidine)" Abbott Pharmaceutical, Abbott Park, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: dexmedetomidine
Brand name: Precedex
Synonyms: Dexmedetomidine
Generic Name: sacubitril / valsartan
Brand name: Entresto
Synonyms: Sacubitril and Valsartan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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