Dexmethylphenidate Hydrochloride and Phenobarbital Injection
Determining the interaction of Dexmethylphenidate Hydrochloride and Phenobarbital Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:According to the manufacturer, methylphenidate may inhibit the metabolism of anticonvulsants including phenobarbital, phenytoin, and primidone. There have been only isolated case reports of phenytoin intoxication during coadministration with methylphenidate and none for the other anticonvulsants. Moreover, two studies found little or no effect of methylphenidate on plasma phenytoin concentrations. Thus, available evidence does not seem to support a clinically significant drug interaction. Nevertheless, it may be appropriate to monitor the pharmacologic response to these anticonvulsants more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the anticonvulsant dosage adjusted as necessary.
- Kupferberg HJ, Jeffery W, Hunninghake DB "Effect of methylphenidate on plasma anticonvulsant levels." Clin Pharmacol Ther 13 (1972): 201-4
- Garrettson LK, Perel JM, Dayton PG "Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate." JAMA 207 (1969): 1053-6
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc, Atlanta, GA.
- "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals, East Hanover, NJ.
- Ghofrani M "Possible phenytoin-methylphenidate interaction." Dev Med Child Neurol 30 (1988): 267
- Mirkin BL, Wright F "Drug interactions: effect of methylphenidate on the disposition of diphenylhydantoin in man." Neurology 21 (1971): 1123-8
Generic Name: dexmethylphenidate
Brand name: Focalin, Focalin XR
Synonyms: Dexmethylphenidate
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexmethylphenidate Hydrochloride-Phenobarbital Oral Solution
- Dexmethylphenidate Hydrochloride-Phenobarbital Sodium
- Dexmethylphenidate Hydrochloride-Phenobarbital Sodium Injection
- Dexmethylphenidate Hydrochloride-Phenobarbital Tablets
- Dexmethylphenidate Hydrochloride-Phenobarbital with Belladonna Alkaloids Elixir
- Dexmethylphenidate Hydrochloride-Phenohytro
- Phenobarbital Injection-Dexmethylphenidate Tablets
- Phenobarbital Injection-DexPak
- Phenobarbital Injection-DexPak 10 Day Taperpak
- Phenobarbital Injection-DexPak 13 DayTaperpak
- Phenobarbital Injection-DexPak 6 DayTaperpak
- Phenobarbital Injection-DexPak Jr